Emergency services were called at 12.55pm with a report of a two vehicle collision on the B4008 Gloucester Road in Standish.
A man in his 30s from Gloucester has been arrested in connection with the collision.
The B4008 Gloucester Road has been closed from the junction for the Javelin Park incinerator, by the church at the junction for Standish Lane, and Horsemarling Lane while emergency services remain at the scene.
The closures are expected to remain in place for a number of hours with motorists asked to plan their route in advance and avoid the area.
Stagecoach has announced that 65 service is being diverted via the a38, advising that the following stops won’t be served: blooms, Harefield turn, St Nicholas’s Church, The Shieling, Oxlynch Lane, The Old Barn and Crowcumepill.
