April 7, 2026, 7:22 a.m. CT
The Sioux Falls business scene is bustling, showcasing a dynamic blend of new ventures, expansions and next chapters that reflect the city’s ever-evolving economic landscape.
Staying in the know about it all can prove challenging for the city dubbed the fastest-growing in the Midwest since 2020.
The Argus Leader is here to help with a regular roundup of Sioux Falls metro area openings, closings and everything in between. We’re calling it, “Let’s Talk Business,” a recap posted regularly, featuring business news and a look at what’s to come in and around the “Queen City.”
Here’s the latest business news:
Have something to add? Email reporter Vanessa Carlson Bender at vbender@gannett.com.
Openings
- Asian Cuisine Express recently opened its Sioux Falls location at the former first Sioux Falls Taco John’s at 1420 W. 41st St. The restaurant currently has a location in South Sioux City, Nebraska. The menu features jalepeno chicken dishes, lo mein, soups, appetizers such as egg rolls, crab rangoon and fried shrimp, seafood, chop suey, egg foo young, vegetarian options, mei fun, a kids’ menu and more. Sushi is on hold for now due to limited kitchen space. Drive-thru and walk-in are available, and hours are 11 a.m. to 9 p.m. Sunday-Thursday and 11 a.m. to 9:30 p.m. Friday and Saturday.
On the move
- On April 3, Junk in the Trunk, a local vintage and upcycled furniture and home decor store, reopened at its new location in Tea at 46930 Cody Trail, Suite A, inside the same building as Bounce Around Inflatables. Junk in the Trunk announced the move on Feb. 18. The store in Sioux Falls was open until March 22, before temporarily closing for the move. The new store location now has updated hours, 10 a.m.-5 p.m. Friday, Saturday and Monday, noon-4 p.m. Sunday and closed Tuesday, Wednesday and Thursday.
Closings
- Intoxibakes, a bakery specializing in alcohol-infused cupcakes as well as non-boozy baked goods, announced on Monday, April 6, that the business will no longer sell items at its downtown storefront beginning at the end of May. Williquors will continue to sell Intoxibakes baked goods, and the business is open to expanding into other locations as well. All 2026 orders and wedding orders already placed will still be fulfilled. New custom orders can still be placed up until the end of May. After May, the consolidated downtown storefront with Candy Cloud Factory will begin adding additional cotton candy machines, ice cream, and candy, and will remain open seven days a week. Intoxibakes took over ownership of Candy Cloud Factory in September 2023 and moved into the candy store one year later, downtown at 701 N. Phillips Ave. on the boardwalk of The Cascade at the Falls apartment complex. Co-owners Holly Jorgenson and her daughter Josie Layton opened Intoxibakes online in November 2017, later adding co-owner Shannon Johnson to the team. The bakery initially moved to downtown Sioux Falls in 2019, then temporarily moved to the Empire Mall in April 2024, and returned downtown in consolidation with the Candy Cloud Factory in September 2024.
Coming soon
- Two new non-profit veterinary hospitals are anticipated to open this spring, initiatives launched by the Hanson Family Foundation for the Well-Being of God’s Creatures. The name of the two vet hospitals, both currently under construction, will be the Pet Wellness Veterinary Hospital (PWVH), South Dakota’s first non-profit veterinary hospital. The west side hospital will be located inside PetSmart at 2818 S. Louise Ave. in Sioux Falls. The 2,000-square-foot veterinary hospital will include three exam rooms, a large medical treatment area, a X-ray room, a surgery suite, a pharmacy, a vet staff office and a breakroom. The other 3,700-square-foot location will be on the east side of Sioux Falls at 4600 E. 59th St. and will include the same amenities, with an additional quiet room with private exit and a meeting room for the foundation. The Hanson Family Foundation is a non-profit organization launched in 2023 with a focus on “keeping pets and their families together” by reducing pet overpopulation, providing affordable veterinary care and removing geographic and financial barriers that force families to surrender their pets to shelters and rescues. PWHV partners with many other organizations like the Best Friends Animal Society, the Sioux Falls Area Humane Society, the Bishop Dudley Hospitality House and other animal shelters in Brookings and Yankton. In 2025, the non-profit launched two other initiatives in Sioux Falls: The Animal Resource Center and the Shepherd’s Stable Equine Center and Sanctuary.
- Early Bird, a national restaurant franchise serving breakfast, brunch and lunch, announced on March 24 that it will open in Sioux Falls at 3101 W. 41st St., the former Jacky’s Burrito Express and Fuddrucker’s space. Jacky’s closed at that location in late March. The goal is to open in August. This will be the first Early Bird location in South Dakota and the franchise’s 10th restaurant to open. Based in Omaha, Nebraska, Eary Bird’s other Midwest locations include Lincoln, Nebraska, and Des Moines and Annkenyk, Iowa, but plans to grow nationally as well. The menu includes items such as cinnamon roll pancakes, bananna bread French toast, breakfast pot pies, bacon flights, breakfast nachos, omelets, burgers, tacos, chicken-fried steak, Philly cheesesteak, hash brown croquettes called “hash holes” and much more. Drink options includea juice bar, as well as mimosas, beer-mosas, cocktails, Early Bird’s original energy drinks, coffee and more. Hours will be 6:30 a.m. to 2:30 p.m. daily.
Vanessa Carlson Bender is the Development and Public Health Reporter at the Sioux Falls Argus Leader. Reach her at vbender@gannett.com.
